Are you familiar with the cannabinoid 10-OH-HHCP?

Text: What is 10-OH-HHCP, green cannabis leaf and question mark
Text: What is 10-OH-HHCP, green cannabis leaf and question mark

 

 

 

 

 

What is 10-OH-HHCP and where did it come from?

10-hydroxy-hexahydrocannabichol, abbreviated 10-OH-HHCP, is a modified version of hexahydrocannabichol (HHCP), specifically a hydroxy derivative of hexahydrocannabichol. HHCP is a synthetic cannabinoid - a derivative of HHC (hexahydrocannabinol). The cannabinoid HHC is found in low amounts in the cannabis plant, but is mostly obtained artificially from CBD (cannabidiol) or terpenes.

HHCP differs from HHC by having a seven-carbon alkyl chain, i.e. two carbons longer. The cannabinoid THCP, for example, also has a seven-carbon chain. Now, how 10-OH-HHCP is born.

10-OH-HHCP is formed when HHCP is oxidised by the liver enzyme cytochrome P450. During this process, a single hydroxyl group (-OH) is added to the tenth carbon of the hexahydrocannabiphorol nucleus. This is a reaction that increases solubility and may possibly alter the interaction with receptors in the body, which will affect how the substance acts.

 

A scientist in the lab makes 10-OH-HHCP in front of him are vials of HHC liquid, HHCP, because 10-OH-HHCP is made from HHCP, which is a derivative of HHC

How does 10-OH-HHCP work in the body?

10-OH-HHCP is thought to have low bioavailability and a short half-life in the body. This means the time during which the concentration of cannabinoids in the blood is halved due to metabolism and excretion.

As with other cannabinoid hydroxyderivatives, 10-OH-HHCP could be metabolised by cytochrome P450 enzymes in the liver, leading to the formation of various metabolites, including inactive ones.

As there are no detailed studies on 10-OH-HHCP yet, it is not possible to tell what metabolic pathways this substance undergoes and what metabolites are formed. Let us consider the most recent study from May 2024, which looked at how the cannabinoid HHC is metabolised in the human body using hepatocytes (liver cells). The study aimed to identify the specific metabolites that are produced and to find out how quickly these compounds are flushed out of the body.

The results showed that HHC is processed in hepatocytes through various metabolic pathways, including oxidation and conjugation, a biochemical process in which small molecules (glucuronide, sulfate, glycine or glutathione) are attached to the metabolised substances to increase water solubility and facilitate excretion from the body.

Effects

It appears that 10-OH-HHCP could have similar effects to tetrahydrocannabinol (THC) HHC or HHCP. There is talk that this substance effectively binds to CB1 receptors in the endocannabinoid system, hence its psychoactive effects.

10-OH-HHCP, like other psychoactive cannabinoids such as THCB, HHC and HHCP, can affect perception, induce feelings of euphoria, relaxation or increase appetite.

The details of exactly how 10-OH-HHCP interacts with receptors in the ECS and what effects it has are not yet explored. The effects will also depend on the route of consumption. For example, oral ingestion may lead to the formation of more inactive metabolites compared to vaporization or sublingual administration.

 

The oil bottle, which denotes oral administration, text: or, and the vaporizer, which denotes the method of vaping, with the effects of 10-OH-HHCP depending on the method of consumption

Side effects

At the moment, we do not even have studies that map the potential adverse effects of 10-OH-HHCP.  We can rely on experience with other psychoactive cannabinoids that may cause adverse reactions in some individuals, such as:

How strongly these effects manifest themselves will depend on the individual's state of health, metabolism and sensitivity, as well as the dosage and method of consumption.

Safety, legality and supply of 10-OH-HHCP products

The most commonly sold 10-OH-HHCP products on the market are vapes, flowers, pre-rolls, hash and gummies.

Regarding the questions about safety, precisely because of the lack of clinical studies, it cannot yet be stated with certainty that the use of 10-OH-HHCP is risk-free. The truth is that until 10-OH-HHCP and other cannabis derivatives are regulated, it is up to consumers to assess the potential risks and benefits of these substances for themselves.

 

Text: Is 10-OH-HHCP legal, cannabis leaf and the concept of legislation

The 10-OH-HHCP products that can be purchased on the market generally contain less than 0.2% THC, making them legal from this perspective. The cultivation of cannabis with up to 0.3% THC was made legal in 2018 by the US Farm Bill. The legal status of 10-OH-HHCP is currently unclear, with the compound likely to be in a grey legal zone in most countries.

Because the regulatory situation for cannabinoids is complex, and this is worldwide, there may be issues with the quality, safety and legality of these products.

If you decide to purchase any cannabis products, choose products from verified and reputable companies that have their products tested in independent laboratories. Some sellers have a "Certificate of Analysis" (COA) posted right next to their products on their e-commerce sites, or feel free to ask for this document.

Summary of information on 10-OH-HHCP

10-OH-HHCP is a hydroxylated derivative of HHCP. It is formed when HHCP is oxidized by the liver enzyme cytochrome P450. During this reaction, a single hydroxyl group (-OH) is added to the tenth carbon of the hexahydrocannabiphorol nucleus.

At the moment, there is a lack of research to evaluate how 10-OH-HHCP works in the body and what its safety is.

Hydroxyderivatives can be expected to have low bioavailability and rapid metabolic breakdown in the body. They are rapidly processed and excreted by the body, which affects both their effectiveness and how long they last.

10-OH-HHCP has psychoactive effects and may affect perception, induce feelings of euphoria, relaxation or increase appetite.

Under no circumstances sit behind the wheel or operate any machinery after use.

  

Author: Horsehog&Cow 

  

  

Photo: ChatGPT

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